Editing modifies the GABAA receptor subunit 3
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چکیده
منابع مشابه
Altered GABAA,slow Inhibition and Network Oscillations in Mice Lacking the GABAA Receptor 3 Subunit
Harald Hentschke, Claudia Benkwitz, Matthew I. Banks, Mark G. Perkins, Gregg E. Homanics, and Robert A. Pearce Department of Anesthesiology, University of Wisconsin, Madison, Wisconsin; Section of Experimental Anesthesiology, Department of Anesthesiology, Eberhard-Karls-University, Tuebingen, Germany; and Departments of Anesthesiology and Pharmacology, University of Pittsburgh School of Medicin...
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Ramadan, Epolia, Zhanyan Fu, Gabriele Losi, Gregg E. Homanics, Joseph H. Neale, and Stefano Vicini. GABAA receptor 3 subunit deletion decreases 2/3 subunits and IPSC duration. J Neurophysiol 89: 128–134, 2003. 10.1152/jn.00700.2002. Deletion of the 3 subunit of the GABAA receptor produces severe behavioral deficits and epilepsy. GABAA receptor-mediated miniature inhibitory postsynaptic currents...
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The GABAA receptor is a chloride-selective ligand-gated ion channel of the Cys-loop superfamily. The receptor consists of five subunits arranged pseudosymmetrically around a central pore. The predominant form of the receptor in the brain contains 1-, 2-, and 2-subunits in the arrangement , counter-clockwise around the pore. GABAA receptors containing instead of -subunits, although a minor compo...
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GABA(A) receptors (GABA(A)Rs) exist as different subtype variants showing unique functional properties and defined spatio-temporal expression pattern. The molecular mechanisms underlying the developmental expression of different GABA(A)R are largely unknown. The intracellular concentration of chloride ([Cl(-)](i)), the main ion permeating through GABA(A)Rs, also undergoes considerable changes d...
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Rapid activation of postsynaptic GABAA receptors (GABAARs) is crucial in many neuronal functions, including the synchronization of neuronal ensembles and controlling the precise timing of action potentials. Although the γ2 subunit is believed to be essential for the postsynaptic clustering of GABAARs, synaptic currents have been detected in neurons obtained from γ2(-/-) mice. To determine the r...
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ژورنال
عنوان ژورنال: RNA
سال: 2007
ISSN: 1355-8382
DOI: 10.1261/rna.349107